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In Canada, men die younger than women, while women experience a heavier burden of chronic illness. Imagine if we only tested prostate cancer drugs on female cell samples, or created anti-smoking campaigns only for men. Does that make sense? Men, women, girls, boys and gender-diverse people are similar in many ways; but, when it comes to our health and well-being, differences matter.
Every cell is sexed and every person is gendered. Sex and gender influence our risk of developing certain diseases, how well we respond to medical treatments, and how often we seek care. Did you know that, in Canada, men typically die younger than women, yet more women struggle with chronic illness? These are complicated questions. The more we understand about how sex and gender affect health, the more we can improve health and well-being for everyone. We use these findings to tackle the biggest health challenges. Our vision includes everybody—men, women, girls, boys and gender- diverse people.
We will transform research methods to ensure health research is more rigorous and its findings generalizable to everyone. We are interdisciplinary. We are international. We are leading science towards the delivery of personalized health at the point of care. It is no longer acceptable for basic science studies to be performed exclusively in male animals, or for women to be excluded from clinical trials.
Sex differences in genetics, epigenetics, molecular biology, immunology and drug metabolism challenge the status quo, one-size-fits-all approach to health and disease. The launch of sex-specific drug dosing over the past five years and the promise of sex-specific therapy heralds a new era of personalized medicine. Gender is emerging as a powerful predictor of cardiac and mental health outcomes. Gender-transformative approaches are improving Women wanting sex Canada way we de, implement and scale up novel health interventions.
Growing recognition of diverse gender identities is not only changing public policy but pushing research to be more inclusive of ly uncounted voices—like those of transgender and Two-Spirit individuals. As the landscape shifts towards better integration of sex and gender in science, the Institute of Gender and Health continues to drive best practices in health research.
Our strategic plan places sex and gender science at the heart of experimental de, measurement, analysis, reporting and implementation. Our journey to integrate, innovate and positively impact health outcomes takes full advantage of the opportunities and challenges that lie ahead.
Sex and gender shape us inside and out—influencing everything from our biology to our behaviour. Sex and gender permeate our lives, while being difficult to recognize and define 1. Putting simple boxes around the complex and interconnected concepts of sex and gender is not easy; however, doing so can help researchers apply the two concepts consistently and distinguish between the many different ways in which sex and gender shape our lives—including our health.Canada Dry Tinder Girl Gets Bad Dating News For Making Him Wait
While it is important to clearly distinguish between sex and gender, we also need to understand the dynamic relationship between these and other factors that influence health and well-being. Intersectional factors— like income, social status and supports, Indigeneity, sexual orientation, education, employment, ability, ethnicity, social and physical environments, geographical location, genetics and personal health practices— contribute to varied experiences and outcomes for men, women, girls, boys and gender-diverse people. As such, IGH is proud to include research that investigates the health and wellness of individuals who identify as LGBTQI2S lesbian, gay, bisexual, transgender, queer and questioning, intersex and Two Spirit among our priorities.
At IGH, we make a distinction between sex and gender while acknowledging that they are interrelated and potentially inseparable. Our understanding of sex and gender and how they intersect with other factors will continue to evolve as research advances. Sex refers to a set of biological attributes in humans and animals. Sex is usually categorized as female or male but there is variation in the biological attributes that comprise sex and how those attributes are expressed. Gender refers to the socially- constructed roles, behaviours, expressions and identities of girls, women, boys, men, and gender- and sexually-diverse people.
It influences how people perceive themselves and others, how they act and interact and the distribution of power and resources in society. There is considerable diversity in how individuals and groups understand, experience and express gender through the roles they take on, the expectations placed on them, relations with others and the complex ways that gender is institutionalized in society. GENDER Socially- constructed roles, behaviours, expressions and identities of girls, women, boys, men and gender-diverse people.
SEX Biological attributes of humans and animals, including physical features, chromosomes, gene expression, hormones and anatomy. There are many similarities between men, women, girls, boys and gender- diverse people; but when it comes to our health and well-being, differences matter. Recognition of these differences began with a focus on reproductive health and now reaches well beyond our anatomy, thanks to a growing body of literature pointing to numerous sex- and gender- based differences extending from the societal level down to our cells.
Sex and gender influence our risk of developing certain diseases, our symptoms and severity of illness, how well we respond to interventions, and how often we seek care. While investigating how patterns differ between groups is important, there is also sex and gender variation within groups that must be considered. We cannot assume, for example, that all women or all men are the same.
We need to understand the mechanisms and pathways underlying the trends we observe, and how sex and gender intersect with other factors like age or income to shape our overall Women wanting sex Canada. To support and champion a health research agenda that embraces sex and gender and is therefore more scientifically rigorous and responsive to the diverse health needs of people in Canada and around the world.
A world where sex and gender are integrated as key considerations across health research and its applications. To foster research excellence regarding the influence of sex and gender on health and to apply these findings to identify and address pressing health challenges facing men, women, girls, boys and gender-diverse people. CIHR provides leadership and support to more than 13, health researchers and trainees across Canada. In investigator-initiated competitions, we promote the integration of sex as a biological variable and gender as a social determinant of health in all research protocols.
We collectively aim to mobilize and translate research evidence into tangible health impacts across Canada and around the world. At the CIHR Institute of Gender and Health, we envision a world where sex and gender are integrated as key considerations across health research and its applications. Our mission is to foster research excellence regarding the influence of sex and gender on health, and to apply these findings to identify and address pressing health challenges facing men, women, girls, boys and gender-diverse people.
Fulfilling our mission requires that IGH be more than a funding institute. IGH plays an important leadership role in advancing knowledge, building capacity in sex and gender science across disciplines and career stages, and accelerating the application of evidence in the real world.
Under the leadership of our Scientific Director and Institute Advisory Board, our role is to champion a health research agenda that embraces sex and gender and is therefore more scientifically rigorous and responsive to the diverse health needs of people in Canada and around the world. Sex and gender intersect all areas of health research—uniquely positioning IGH to collaborate broadly across disciplines, research themes and institutes both within CIHR and beyond it. For 17 years, we have supported research that fills critical knowledge gaps across diverse areas, including mental health, cancer, heart disease, substance use, sexual and reproductive health, violence, and workplace health and wellbeing.
We have also fostered innovation through transdisciplinary partnerships outside of the health sciences. IGH is unique on the international health research stage. Recognized as the only national research institution in the world with a dedicated mandate in sex, Women wanting sex Canada and health research, IGH positions Canada as Women wanting sex Canada global leader in the creation and translation of knowledge in this area. As a result, IGH has developed a network of international partners and collaborators in 21 countries.
Fromwe advocated for the integration of sex and gender in funding, ethics, publishing and policy and we launched three online training modules. We invested over six million dollars in supplemental funding to encourage basic scientists to consider sex as a biological variable in their research. We contributed scientific leadership on major initiatives including personalized health, cannabis, opioids, indigenous health and others.
We worked with the College of Reviewers and the Competition Chairs to improve the quality assessment of sex and gender in peer review. We funded teams to investigate the added value of addressing gender in knowledge translation interventions. We helped narrow the gap between research evidence and policy in a first-ever Policy- Research Partnership with Health Canada. We leveraged the power of a global academic- pharma-regulatory agency alliance to accelerate the delivery of personalized drug therapy at the point of care.
We ran Hackathons and De Jams to spark innovation and mobilize knowledge into action. We led Best Brain Exchange events with the provinces around sex- and gender-based analysis. We convinced professional medical societies to re-think their clinical practice guidelines to include sex- and gender-specific evidence.
We brainstormed with the Association of Faculties of Medicine of Canada on how to change medical curricula to better integrate sex- and gender-specific medicine for the next generation of physicians and allied health-care professionals. The next few s highlight some of our key activities and accomplishments. These are our accomplishments so far.
We list them here to illustrate why we and the IGH community feel it is important to continue on this successful trajectory—leveraging the global momentum and political will we have helped to build. More than 60 Sex and Gender Champions are now funded across a variety of CIHR funding initiatives and have formed a community of practice. By the end ofit had over 1, successful completions.
By the end ofboth modules had more than successful completions each. IGH takes a leadership role in the promotion of the guidelines by holding webinars for Canadian journal editors and publishing articles in Nature. Stemming from a of IGH presentations, CIHR develops a sex- and gender-based analysis in research action plan, to be rolled out from The Canadian Association of Research Ethics Boards endorses the implementation of sex- and gender-based analysis.
Sex Differences in Chronic Pain The generally-accepted notion in pain research has been that immune cells called microglia are responsible for transmitting pain through the nervous system; however, this theory is based on experiments performed overwhelmingly in male rodents only. Jeffrey Mogil and Dr. Michael Salter, researchers interfered with microglia functioning and found striking sex differences. While blocking microglia functioning reduced pain in male mice, it had no effect on pain transmission in female mice.
This discovery, published in Nature Neuroscience inhas ificant implications for the field of pain research and demonstrates the potential for scientific discovery offered by sex- and gender-based analysis. There are important sex differences in cardiovascular disease. By developing and applying a novel gender index, researchers were able to measure sex and gender independently.
These findings suggest that personality traits and social roles typically ased to or associated with women may increase the risk of negative outcomes in patients with cardiac disease. A combination? A thorough analysis of both sex- and gender-related factors has the potential to break new ground and improve health outcomes for individuals of all genders.
This unique collaboration not only brings together health and social science researchers but also fosters meaningful Women wanting sex Canada of knowledge user partners. This unique event helps create connections across disciplines by connecting researchers developers, deers and people with lived experience of mental health challenges to spark innovation in mental health. As an international leader in sex and gender integration Women wanting sex Canada the health sciences, IGH is often invited to share promising practices and the latest science in the field.
Most recently, we have been invited to present at the following meetings:. Research organizations are increasingly aware that good science must not only for sex and gender but must do so in a way that is transgender- trans- inclusive. Greta Bauer and colleagues have evaluated population health survey methods to determine the most effective trans-inclusive approach to population surveys. Bauer points out that existing measures leave gaps in ing for sex and gender where trans participants are concerned. InDr. Bauer published a new multidimensional sex and gender measure deed to be trans- inclusive.
This tool will allow population health researchers to be more inclusive of transgender individuals and better measure and collect sex and gender data. There are more than 5.
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